AMBOSS Step 1 ESSENTIALS kit
50 high-yield USMLE® Step 1 topics

Feeling ready for your big Step? Make sure you master these 50 most high-yield topics for the USMLE® Step 1 exam. This list has been compiled by our team of expert physician editors and the excellent AMBOSS analytics team to provide an empathic boost to your preparations (On average, AMBOSS users score up to 12 points higher on the USMLE® Step 1*)

* – As the Step 1 exam moves to pass/fail from January 26, 2022, students will no longer receive a three-digit score. Read what AMBOSS physicians have to say about adapting to this change and get their advice on how to study for the new Step 1 exam.
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Create an AMBOSS account to access all of the below-listed topics and stay ahead of the game.

‍Please read the instructions at the bottom of the page for useful tips on how to use this kit effectively

The top 50 high-yield USMLE® Step 1 topics

  1. Overview of antibiotic therapy
  2. Bacteria overview
  3. Inborn errors of metabolism
  4. Diabetes mellitus
  5. Airways and lungs
  6. Congenital immunodeficiency disorders
  7. General virology
  8. Epidemiology
  9. Stroke
  10. Vitamins
  11. Cardiovascular physiology
  12. Congestive heart failure
  13. Cellular changes and adaptive responses
  14. Erythrocyte morphology and hemoglobin
  15. Acute coronary syndrome
  16. Hypersensitivity reactions
  17. Chemotherapeutic agents
  18. Opioids
  19. Physiology of the kidney
  20. Pneumonia
  21. Cranial nerve palsies
  22. Cholelithiasis, choledocholithiasis, cholecystitis, and cholangitis
  23. Breast cancer
  24. Chronic obstructive pulmonary disease
  25. Antidepressants
  1. Hepatitis B
  2. Hemostasis and bleeding disorders
  3. Immunosuppressants
  4. Diuretics
  5. Peripheral nerve injuries
  6. Infective endocarditis
  7. Signal transduction
  8. Gastrointestinal tract
  9. Disorders of sex development
  10. Cytokines
  11. Acute leukemia
  12. Adaptive immune system
  13. Asthma
  14. General oncology
  15. Basics of hematology
  16. Lung cancer
  17. Human immunodeficiency virus
  18. Basics of human genetics
  19. Nephrotic syndrome
  20. Cardiomyopathy
  21. Antidiabetic drugs
  22. Antipsychotics
  23. Meningitis
  24. Brain tumors
  25. Nephrolithiasis

How do I get the most out of the Step 1 ESSENTIALS kit?

  1. Each of the 50 topics can be found within the AMBOSS Knowledge Library and Qbank. To access them, you need to create an AMBOSS account, if you don’t already have one.
  2. Once that is done, feel free to bookmark this page and go through the topics at a pace that works for your study schedule; as soon as you finish studying one, come back to this page to see what comes up next. It’s an easy way to ensure you don’t drop easy points during this all important exam!
  3. Try the following tips:
  4. Test yourself as often as you can. The grey arrow at the top of each Learning Card leads to a USMLE®-style Qbank session covering all the tested concepts from the topic you’re reviewing.
  5. Really use the features like High-Yield Mode, Highlighting, pop-up definitions and more, which will help you pick out key points quickly and condense your study time.
  6. Add your own personal notes to the Learning Cards to build upon your knowledge and keep all your learnings in one place.
  7. Gain valuable insights through our blog-posts that will give you  an added push towards your goal:
  8. USMLE Step 1: What You Need to Know
  9. Studying for the USMLE Step 1 Exam
  10. You Need More than Just a Qbank for Step 1
  11. USMLE® Step 1 Match Scores by Medical Specialty
LOG IN / CREATE FREE ACCOUNT


So, are you ready to take Step 1 by storm? Create your AMBOSS account here and activate 5 days of FREE access to explore the platform. Already have an account? There are plans for as little as $9 per month that will give you unlimited access to all the topics listed in this highly impactful Study Plan.

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